Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia.
Med J Aust. 2010 Aug 16;193(4):213-6. doi: 10.5694/j.1326-5377.2010.tb03870.x.
To document trends in subject demographics, anthropometry and sleep disorder severity over 21 years of diagnostic sleep studies.
DESIGN, PARTICIPANTS AND SETTING: A retrospective observational study of consecutive subjects undergoing initial diagnostic polysomnography for investigation of possible sleep disorders in a university-affiliated tertiary public metropolitan hospital in the Hunter New England region of New South Wales between 1987 and 2007.
Body weight, body mass index (BMI) and severity of sleep-related breathing disorders (apnoea-hypopnoea index [AHI]).
Between 1987 and 2007, 14 648 new diagnostic sleep studies were performed. The median age of subjects (51 years; interquartile range, 41-61 years) did not change over time and the proportion of women increased from 20% to 39%. Median body weight increased from 89 kg to 99 kg for men (11%) and from 73 kg to 85 kg for women (16%), equating to a yearly increase in median BMI of 0.15 kg/m(2) for men and 0.14 kg/m(2) for women. The proportion of subjects who were morbidly obese (BMI > or = 40) increased from 3% in 1987 to 16% in 2007. Median AHI progressively increased from 1992-1995 to 2004-2007 (from 6.5 events/h to 14.3 events/h; P < 0.001), indicating increasing disease severity. Over the same period, for every unit increase in BMI, AHI increased by 5.5 events/h for men and by 2.8 events/h for women. About 80% of the observed variance in AHI over this period was attributable to variance in BMI.
There is a continuing trend towards increasing body weight and BMI in people undergoing diagnostic sleep studies. Our data do not support the hypothesis that increased accessibility to diagnostic services and increased awareness of sleep disorders are resulting in a decline in disease severity. These findings are consistent with the premise that worsening severity in sleep-disordered breathing is primarily attributable to increasing obesity.
记录 21 年来诊断性睡眠研究中受试者人口统计学、人体测量学和睡眠障碍严重程度的变化趋势。
设计、参与者和设置:对新南威尔士州亨特新英格兰地区一所大学附属的三级公立大都市医院 1987 年至 2007 年间进行的初始诊断性多导睡眠图检查以调查可能的睡眠障碍的连续受试者进行回顾性观察性研究。
体重、体重指数(BMI)和睡眠相关呼吸障碍(呼吸暂停低通气指数[AHI])的严重程度。
1987 年至 2007 年间,进行了 14648 项新的诊断性睡眠研究。受试者的中位年龄(51 岁;四分位间距,41-61 岁)没有随时间变化,女性比例从 20%增加到 39%。男性体重中位数从 89kg 增加到 99kg(11%),女性体重中位数从 73kg 增加到 85kg(16%),相当于男性 BMI 中位数每年增加 0.15kg/m2,女性每年增加 0.14kg/m2。BMI 大于或等于 40 的肥胖症患者比例从 1987 年的 3%增加到 2007 年的 16%。中位 AHI 从 1992-1995 年至 2004-2007 年逐渐增加(从 6.5 次/h 增加到 14.3 次/h;P <0.001),表明疾病严重程度逐渐增加。在此期间,BMI 每增加一个单位,男性的 AHI 增加 5.5 次/h,女性增加 2.8 次/h。在此期间,AHI 变化的约 80%归因于 BMI 的变化。
进行诊断性睡眠研究的人群体重和 BMI 持续呈上升趋势。我们的数据不支持这样的假设,即诊断服务的可及性增加和对睡眠障碍的认识提高导致疾病严重程度下降。这些发现与这样的前提一致,即睡眠呼吸障碍严重程度的恶化主要归因于肥胖症的增加。