慢性哮喘患者使用降钙素鼻喷雾剂：与安慰剂对比的双盲交叉研究
Calcitonin nasal spray in patients with chronic asthma: a double-blind crossover study vs placebo.
作者信息
Dal Negro R, Turco P, Pomari C, Trevisan F
机构信息
Department of Clinical Respiratory Physiology, Bussolengo General Hospital, Verona, Italy.
出版信息
Int J Clin Pharmacol Ther Toxicol. 1991 Apr;29(4):144-6.
The study, which was of a double-blind, crossover type vs placebo in 12 subjects suffering from postmenopausal osteoporosis and chronic asthma, evaluates the effects of acute, prolonged administration of salmon calcitonin (sCT) nasal spray on respiratory function (FEV1, MMEF, V25). No significant changes in bronchomotor tone were observed as a result of prolonged treatment with sCT nasal spray, thereby confirming the complete tolerability of the formulation.
这项针对12名患有绝经后骨质疏松症和慢性哮喘的受试者进行的双盲交叉对照安慰剂研究，评估了急性、长期给予鲑鱼降钙素（sCT）鼻喷雾剂对呼吸功能（第一秒用力呼气容积、最大呼气中期流速、25%肺活量时的呼气流量）的影响。长期使用sCT鼻喷雾剂治疗后，未观察到支气管运动张力有显著变化，从而证实了该制剂具有完全耐受性。
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