Weinberg D V, Kolodny N H, Kohler S J, Burr T A, Celi A, D'Amico D J, Gragoudas E S
Retina Service, Massachusetts Eye & Ear Infirmary, Boston 02114.
Invest Ophthalmol Vis Sci. 1991 Jul;32(8):2212-8.
Ocular images were obtained using sodium chemical shift imaging (CSI) and 1,4,7,10-tetraazacyclododecane-N,N'N",N"'-tetramethylenephospho nate thulium (III) [Tm(DOTP)5-], a paramagnetic chemical shift reagent. After injecting the shift reagent into the anterior chamber of rabbits, serial imaging was done, monitoring the change in chemical shift with time. Sodium CSI produced images of the eye in three dimensions, quantitatively depicting the spatial and temporal changes in the concentration of a paramagnetic tracer substance. The Tm(DOTP)5- is eliminated from the anterior chamber by first-order kinetics with a half-life of 49 min. These data suggest that this substance is eliminated from the anterior chamber at the same rate as aqueous humor is replaced. Sodium CSI shows promise as a valuable technique for monitoring fluid dynamics in the living eye.
使用钠化学位移成像（CSI）和1,4,7,10-四氮杂环十二烷-N,N',N'',N'''-四甲基膦酸铥（III）[Tm(DOTP)5-]（一种顺磁化学位移试剂）获取眼部图像。将该位移试剂注入兔眼前房后，进行连续成像，监测化学位移随时间的变化。钠CSI生成了眼部的三维图像，定量描绘了顺磁示踪物质浓度的空间和时间变化。Tm(DOTP)5-以前一级动力学从眼前房消除，半衰期为49分钟。这些数据表明，该物质从眼前房的消除速率与房水的更替速率相同。钠CSI有望成为监测活体眼睛流体动力学的一项有价值的技术。
