Department of Health Outcomes & Behavior, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33613, USA.
Hum Reprod. 2010 Oct;25(10):2543-50. doi: 10.1093/humrep/deq207. Epub 2010 Aug 16.
Pre-implantation genetic diagnosis (PGD) is an assisted reproductive technology procedure which provides parents with the option of conducting genetic analyses to determine if a mutation is present in an embryo. Though studies have discussed perceptions of PGD from a general population, couples or high-risk women, no studies to date have specifically examined PGD usage among men. This study sought to explore perceptions and attitudes towards PGD among males who either carry a BRCA mutation or have a partner or first degree relative with a BRCA mutation.
A cross-sectional survey was conducted among 228 men visiting the Facing Our Risk of Cancer Empowered or Craigslist website. Eligibility criteria included men who self-reported they had been tested for a BRCA mutation or had a partner or first degree relative tested for a BRCA mutation. A 41-item survey assessed socio-demographic, clinical characteristics, PGD knowledge and attitudinal factors and consideration of the use of PGD. Differences in proportions of subgroups were tested using the Monte Carlo exact test for categorical data. A multiple logistic regression model was then built through a backward elimination procedure.
Although 80% of men reported being previously unfamiliar with PGD, after learning the definition of PGD, 34% of the 228 respondents then said they would 'ever consider the use of PGD'. Respondents who thought of PGD only in terms of 'health and safety' were almost three times more likely (OR = 2.82; 95% 1.19-6.71) to 'ever consider the use of PGD' compared with respondents who thought of PGD in terms of both 'health and safety', and 'religion and morality'.
As with other anonymous web-based surveys, we cannot verify clinical characteristics that may impact consideration of PGD use. Our findings indicate high-risk men need more information about PGD and may benefit from educational materials to assist them in reproductive decision-making.
胚胎植入前遗传学诊断（PGD）是一种辅助生殖技术，为父母提供了进行基因分析的选择，以确定胚胎中是否存在突变。虽然已有研究从一般人群、夫妇或高风险女性的角度讨论了对 PGD 的看法，但迄今为止尚无研究专门探讨男性对 PGD 的使用情况。本研究旨在探索携带 BRCA 突变或伴侣或一级亲属携带 BRCA 突变的男性对 PGD 的看法和态度。
对访问 Facing Our Risk of Cancer Empowered 或 Craigslist 网站的 228 名男性进行了横断面调查。入选标准包括自我报告接受 BRCA 突变检测或伴侣或一级亲属接受 BRCA 突变检测的男性。一项包含 41 个条目的调查问卷评估了社会人口统计学、临床特征、PGD 知识和态度因素以及对 PGD 使用的考虑。使用蒙特卡罗精确检验对分类数据进行亚组比例差异检验。然后通过向后消除程序构建了多因素逻辑回归模型。
尽管 80%的男性表示之前不熟悉 PGD，但在了解了 PGD 的定义后，228 名受访者中有 34%表示他们“将考虑使用 PGD”。与认为 PGD 仅关乎“健康和安全”的受访者相比，仅从“健康和安全”角度考虑 PGD 的受访者更有可能（OR=2.82；95%置信区间 1.19-6.71）“将考虑使用 PGD”。
与其他匿名网络调查一样，我们无法验证可能影响 PGD 使用考虑的临床特征。我们的研究结果表明，高危男性需要更多关于 PGD 的信息，并且可能受益于教育材料，以帮助他们进行生殖决策。
