Nagamine Masanori, Mimura Masaru, Reiss Allan L, Hoeft Fumiko
Department of Psychiatry, Japan Self Defense Force Fukuoka Hospital, Kasuga-shi, Fukuoka, Japan.
Brain Nerve. 2010 Aug;62(8):877-84.
Recent advances in social cognitive neuroscience have led to the concept of the "social brain". The social brain includes neural processes specialized for processing social information necessary for the recognition of self and others, and interpersonal relationships. Because of its unique behavioral phenotypic features which includes 'hypersociability', Williams syndrome has gained popularity among social cognitive neuroscientists. Individuals with Williams syndrome share the same genetic risk factor for cognitive-behavioral dysfunction utilizing brain imaging to elucidate endophenotype provides us with an unprecendented opportunity to study gene, brain and behavior relationships especially those related to social cognition. In this review, we provide an overview of neuroimaging studies on social cognition in Williams syndrome and discuss the neural basis of the social brain.
社会认知神经科学的最新进展催生了“社会脑”这一概念。社会脑包括专门用于处理识别自我与他人以及人际关系所需社会信息的神经过程。由于威廉姆斯综合征具有包括“高度社交性”在内的独特行为表型特征，它在社会认知神经科学家当中受到了广泛关注。威廉姆斯综合征患者具有相同的认知行为功能障碍遗传风险因素，利用脑成像来阐明内表型为我们提供了一个前所未有的机会，以研究基因、大脑与行为之间的关系，尤其是那些与社会认知相关的关系。在这篇综述中，我们概述了关于威廉姆斯综合征社会认知的神经影像学研究，并讨论了社会脑的神经基础。
