Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Department of Clinical Neurology, University of Oxford, Oxford, UK.
Restor Neurol Neurosci. 2010;28(4):425-36. doi: 10.3233/RNN-2010-0553.
Repetitive Transcranial Magnetic Stimulation (rTMS) paradigms are showing increasing promise as tools for neurorehabilitation in a variety of chronic neurological and psychiatric conditions. However, the mechanisms by which they modulate cortical activation are still not completely understood. In this review we summarize what non-invasive magnetic resonance imaging techniques can tell us about the cortical effects of rTMS - from changes at a cellular level within the stimulated motor cortex, to modulating activation patterns within the wider motor network. We discuss how variation in these effects in stroke patients may inform our understanding of how rTMS could improve function in these patients.
重复经颅磁刺激（rTMS）模式在各种慢性神经和精神疾病的神经康复中显示出越来越大的潜力。然而，它们调节皮层激活的机制仍不完全清楚。在这篇综述中，我们总结了非侵入性磁共振成像技术可以告诉我们关于 rTMS 的皮层效应的内容 - 从刺激运动皮层内的细胞水平变化，到调节更广泛的运动网络内的激活模式。我们讨论了这些效应在中风患者中的变化如何使我们更好地理解 rTMS 如何改善这些患者的功能。
