Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China 215123.
Chem Commun (Camb). 2010 Sep 28;46(36):6708-10. doi: 10.1039/c0cc01857k. Epub 2010 Aug 16.
A water-soluble, pH-responsive copolymer was synthesized successfully and used as a polymeric carrier to deliver hydrophobic paramagnetic nanoparticles into cells. In an acidic environment, the nanoparticles aggregate as the copolymer degrades, resulting in the enhancement of an in vitro MRI signal.
成功合成了一种水溶性、pH 响应性共聚物，并将其用作聚合物载体将疏水性顺磁纳米粒子递送到细胞内。在酸性环境下，随着共聚物的降解，纳米粒子聚集，导致体外 MRI 信号增强。
