Ogilvie G K, Vail D M, Klein M K, Powers B E, Dickinson K
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
J Am Vet Med Assoc. 1991 May 15;198(10):1762-4.
Nine dogs with intermediate- or high-grade lymphoma were prospectively entered into a protocol to be given a total of 15 weekly doses of doxorubicin (10 mg/m2 of body surface, IV) in an attempt to eliminate all clinical evidence of neoplasia, with minimal risk of drug toxicity. Eight of these dogs did not complete the protocol because of progression of the disease. The median number of doses administered to dogs that developed progressive disease before the regimen was completed was 5 (range, 2 to 9). Seven dogs achieved partial (n = 5) or complete (n = 2) remission, with median duration of 14 days (range, 7 to 231 days). The dog that was given all 15 weekly treatments remained in complete remission for 231 days. Complete remission that lasted for 14 days was observed in another dog. Toxicosis developed in 3 dogs; signs of toxicosis were generally mild and included colitis (n = 1), vomiting (n = 1), neutropenia (n = 1), and lethargy (n = 1). The lowest neutrophil count (1,876 cells/microliter) was seen in one dog after 7 doses of doxorubicin were given. Doxorubicin at dosage of 10 mg/m2/wk appears to be safe, but is generally ineffective for treatment of lymphoma.
9只患有中高级别淋巴瘤的犬被前瞻性纳入一项方案，每周共给予15剂阿霉素（10mg/m²体表面积，静脉注射），试图消除所有肿瘤的临床证据，同时使药物毒性风险降至最低。其中8只犬因疾病进展未完成该方案。在方案完成前病情进展的犬所接受的剂量中位数为5剂（范围为2至9剂）。7只犬实现了部分缓解（n = 5）或完全缓解（n = 2），缓解持续时间中位数为14天（范围为7至231天）。接受了全部15次每周治疗的犬持续完全缓解231天。在另一只犬中观察到持续14天的完全缓解。3只犬出现中毒；中毒迹象通常较轻，包括结肠炎（n = 1）、呕吐（n = 1）、中性粒细胞减少（n = 1）和嗜睡（n = 1）。一只犬在给予7剂阿霉素后出现最低中性粒细胞计数（1876个细胞/微升）。每周10mg/m²剂量的阿霉素似乎是安全的，但通常对淋巴瘤治疗无效。
