Department of Oncology, Pulmonary Hospital, Tongji University School of Medicine, 507# Zhengmin Road, Yangpu Region, 200433, Shanghai, China.
Med Oncol. 2011 Dec;28(4):1453-7. doi: 10.1007/s12032-010-9645-6. Epub 2010 Aug 17.
To investigate whether expression of several cytokines affected clinical outcome in non-small cell lung cancer patients. A total of 86 stage IIIB/IV non-small cell lung cancer patients, treated with platinum-based doublets, were examined expression levels of IL-1, IL-2R, IL-5, IL-6, IFN-γ, TNF-α pre- and post-chemotherapy. Enzyme-linked immunosorbent assay technique was performed. Kaplan-Meier analysis and Cox regression analyses were used to adjust for possible confounding variables. IL-6 expression levels were significantly decreased due to chemotherapy in patients with stable disease (P=0.041). IL-2R expression levels were significantly increased due to chemotherapy in patients with progression disease (P=0.010). Patients with high concentrations of TNF post-chemotherapy had a significantly longer survival (P=0.009, 17 months versus 11 months) than low levels. Multivariate analysis showed that sex, response rate, IL-1 and TNF-α were significantly predictive of the survival. Serum IL-6 and IL-2R levels correlated with chemoresponse in advanced non-small cell lung cancer, serum IL-1 and TNF-α can be predictive factors in advanced non-small cell lung cancer.
为了研究几种细胞因子的表达是否影响非小细胞肺癌患者的临床结局。对 86 例接受铂类双联化疗的 IIIB/IV 期非小细胞肺癌患者，检测化疗前后白细胞介素 1（IL-1）、白细胞介素 2 受体（IL-2R）、白细胞介素 5（IL-5）、白细胞介素 6（IL-6）、干扰素 γ（IFN-γ）和肿瘤坏死因子 α（TNF-α）的表达水平。采用酶联免疫吸附试验技术。采用 Kaplan-Meier 分析和 Cox 回归分析调整可能的混杂因素。在疾病稳定的患者中，化疗后 IL-6 表达水平显著降低（P=0.041）。在疾病进展的患者中，化疗后 IL-2R 表达水平显著升高（P=0.010）。化疗后 TNF-α 浓度高的患者的生存时间明显长于浓度低的患者（P=0.009，17 个月比 11 个月）。多因素分析表明，性别、缓解率、IL-1 和 TNF-α 是生存的显著预测因素。晚期非小细胞肺癌患者血清 IL-6 和 IL-2R 水平与化疗反应相关，血清 IL-1 和 TNF-α 可作为晚期非小细胞肺癌的预测因子。
