统计运动单位数量估计与肌萎缩侧索硬化症试验：运动单位不稳定性的影响。

Statistical motor unit number estimation and ALS trials: the effect of motor unit instability.

作者信息

Shefner Jeremy M

机构信息

Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

出版信息

Suppl Clin Neurophysiol. 2009;60:135-41. doi: 10.1016/s1567-424x(08)00013-5.

DOI:10.1016/s1567-424x(08)00013-5

PMID:20715375

Abstract

Although statistical MUNE has many positive attributes, it is inappropriate for use in multicenter ALS clinical trials. No other commonly used technique for MUNE possesses all the attributes necessary to be a valid and useful outcome measure in ALS trials. However, MUNE as a theoretical outcome measure remains extremely attractive and new techniques must be sought so that it can reach its full potential as a valid and reproducible outcome measure in ALS clinical trials.

摘要

尽管统计学运动单位数目估计（MUNE）有许多积极特性，但它不适用于多中心肌萎缩侧索硬化症（ALS）临床试验。没有其他常用的MUNE技术具备在ALS试验中作为有效且有用的疗效指标所需的所有特性。然而，MUNE作为一种理论上的疗效指标仍然极具吸引力，必须探索新的技术，以便它能在ALS临床试验中充分发挥其作为有效且可重复的疗效指标的潜力。