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[肝功能不全患者的心脏手术;术前评估、决定因素及后果]

[Cardiac surgery in patients with liver dysfunction; preoperative assessment, determinants, and consequences].

作者信息

Matsumoto Kazuhisa, Sakata R

机构信息

Department of Thoracic and Cardiovascular Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

出版信息

Kyobu Geka. 2008 Jul;61(8 Suppl):649-55.

Abstract

The population of patients with liver cirrhosis and congestive liver who are referred for cardiac operation is not large and definitive indications for surgical interventions remain unknown. We reviewed the literature on its clinical features and outcomes after cardiac surgery that would help cardiac surgeons to decide cardiac modality. According to our experiences, in cirrhotic patients, cardiac surgery can be performed safely in Child-Pugh class A and selected patients with class B. In addition, liver cirrhosis causes postoperative deterioration of liver function, especially when the indocyanine green (ICG)-R15 value exceeds 40%. Technetium-99m galactosyl human serum albumin liver scintigraphy is also useful for preoperative assessment. In patients with congestive liver, preoperative serum total bilirubin and technetium-99m galactosyl human serum albumin liver scintigraphy may become the determinant of indications. Careful patient selection and intensive perioperative care are required to improve the clinical outcome in patients with liver dysfunction undergoing cardiac surgery.

摘要

因心脏手术而转诊的肝硬化和充血性肝患者群体数量不大,手术干预的明确指征仍不明确。我们回顾了有关其临床特征及心脏手术后结局的文献,这将有助于心脏外科医生决定心脏手术方式。根据我们的经验,对于肝硬化患者,Child-Pugh A级及部分B级患者可安全地进行心脏手术。此外,肝硬化会导致术后肝功能恶化,尤其是当吲哚菁绿(ICG)-R15值超过40%时。锝-99m半乳糖基人血清白蛋白肝脏闪烁扫描对术前评估也很有用。对于充血性肝患者,术前血清总胆红素和锝-99m半乳糖基人血清白蛋白肝脏闪烁扫描可能成为指征的决定因素。对于接受心脏手术的肝功能不全患者,需要仔细选择患者并进行强化围手术期护理,以改善临床结局。

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