El-Daly Hesham, Gudi Mihir
Histopathology Department, Hammersmith Hospital, Imperial Healthcare National Health Service Trust, London, UK.
Acta Cytol. 2010 Jul-Aug;54(4):560-2. doi: 10.1159/000325177.
To evaluate the sensitivity and specificity of nipple discharge cytology and to determine the diagnostic value of the presence of red blood cells (RBCs) in cases with negative cytology.
Samples were received either as air-dried or alcohol-fixed slides. All cytology cases were reported by cytopathologists in the Hammersmith Pathology Department.
We identified 98 consecutive female patients with nipple discharge cytology in the Hammersmith and Charing Cross hospitals during the period of May 2007 to May 2009. The cytodiagnoses were as follows: 86 cases had negative cytology, 9 cases were C3 (atypia but likely benign), and 3 cases were suspicious for or consistent with malignancy. Thirty of these cases had subsequent biopsy and showed: 9 benign cases, 3 cases with atypical papilloma and 3 cases with a malignant diagnosis (in situ and/or invasive ductal carcinoma). All suspicious and malignant cases with available macroscopic description (whether positive or negative on nipple discharge cytology) were blood stained and on microscopy contained RBCs.
Nipple discharge cytology is a useful method in the diagnosis of malignant and suspicious cases. Further evaluation is needed to assess the value of the presence of RBCs in cases with negative cytology and its correlation with a subsequent diagnosis of malignancy.
评估乳头溢液细胞学检查的敏感性和特异性，并确定细胞学检查阴性病例中红细胞（RBC）存在的诊断价值。
样本以空气干燥或酒精固定玻片形式接收。所有细胞学病例均由哈默史密斯病理科的细胞病理学家报告。
我们在2007年5月至2009年5月期间，在哈默史密斯医院和查令十字医院连续鉴定出98例乳头溢液细胞学检查的女性患者。细胞诊断结果如下：86例细胞学检查阴性，9例为C3（非典型但可能为良性），3例可疑或符合恶性肿瘤。其中30例随后进行了活检，结果显示：9例为良性病例，3例为非典型乳头状瘤，3例为恶性诊断（原位和/或浸润性导管癌）。所有有可用宏观描述的可疑和恶性病例（无论乳头溢液细胞学检查结果是阳性还是阴性）均有血染，显微镜检查含有红细胞。
乳头溢液细胞学检查是诊断恶性和可疑病例的有用方法。需要进一步评估细胞学检查阴性病例中红细胞存在的价值及其与随后恶性肿瘤诊断的相关性。
