Department of Immunology, Institutes of Medical Sciences, Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Cell Immunol. 2010;265(2):105-10. doi: 10.1016/j.cellimm.2010.07.010. Epub 2010 Jul 30.
Vasoactive intestinal peptide (VIP) is a well-known anti-inflammatory neuropeptide. The capacity of VIP can be exhibited through inhibiting inflammatory responses, shifting the Th1/Th2 balance in favor of anti-inflammatory Th2 immunity and inducing regulatory T cells (Tregs) with suppressive activity. In addition to pro-inflammatory Th1 response, Th17 are also believed to play important roles in the pathogenesis of rheumatoid arthritis (RA). In this study, we used collagen-induced arthritis (CIA) model in Wistar rats to investigate the role of VIP in the balance of CD4(+) CD25(+) Tregs and Th17 on RA. Data presented here showed that administration of VIP decreased incidence and severity of CIA. Disease suppression was associated with the upregulation of CD4(+) CD25(+) Tregs, downregulation of Th17- and Th1-type response and influence on the RANK/RANKL/OPG system. The results provide novel evidence that the therapeutic effects of VIP on CIA rats were associated with the balance of CD4(+) CD25(+) Tregs and Th17.
血管活性肠肽（VIP）是一种众所周知的抗炎神经肽。VIP 的作用可以通过抑制炎症反应、有利于抗炎性 Th2 免疫的 Th1/Th2 平衡转变以及诱导具有抑制活性的调节性 T 细胞（Tregs）来体现。除了促炎性 Th1 反应外，Th17 也被认为在类风湿关节炎（RA）的发病机制中发挥重要作用。在这项研究中，我们使用 Wistar 大鼠胶原诱导性关节炎（CIA）模型来研究 VIP 在 RA 中 CD4+CD25+Tregs 和 Th17 平衡中的作用。本文提供的数据表明，VIP 的给药可降低 CIA 的发生率和严重程度。疾病抑制与 CD4+CD25+Tregs 的上调、Th17 和 Th1 型反应的下调以及对 RANK/RANKL/OPG 系统的影响有关。结果提供了新的证据，表明 VIP 对 CIA 大鼠的治疗效果与 CD4+CD25+Tregs 和 Th17 的平衡有关。
