Department of Radiation Oncology, Odette Cancer Centre, Toronto, Ontario, Canada.
Clin Oncol (R Coll Radiol). 2010 Dec;22(10):844-9. doi: 10.1016/j.clon.2010.07.014. Epub 2010 Aug 15.
The primary objective of this study was to assess the rate of tumour response to the palliative radiotherapy regimen used at our centre (8 Gy/fraction on days 0, 7, 21) for non-melanoma skin cancer. The secondary objective was to evaluate symptom palliation.
A retrospective chart review identified patients treated with this palliative radiotherapy regimen from August 2003 to December 2008. Patient age, gender, tumour histology, location, size, presenting symptoms and radiation treatment factors were recorded at baseline. The tumour size and tumour-related symptoms were recorded at each fraction and follow-up visit. The results were analysed on an intent to treat basis.
Twenty-eight patients received 31 courses of palliative radiation for basal cell (five) or squamous cell (26) carcinoma of the skin. Twenty-one patients with 23 tumours attended at least one follow-up visit, and seven patients had incomplete follow-up data. At the time of last follow-up (median 17 weeks), the response rate was 58.1% (complete response 15/31; partial response 3/31). A complete response to treatment was correlated with a smaller tumour size at day 21 (P=0.0143). Presenting symptoms were alleviated in 61.3% (19/31) of symptomatic sites. No severe late toxicities were seen.
This palliative regimen offers impressive response rates and effective symptom palliation for patients with non-melanoma skin cancer.
本研究的主要目的是评估我们中心使用的姑息性放疗方案（0 天、7 天和 21 天，每次 8 Gy）治疗非黑素瘤皮肤癌的肿瘤缓解率。次要目的是评估症状缓解情况。
回顾性病历分析确定了 2003 年 8 月至 2008 年 12 月期间接受该姑息性放疗方案治疗的患者。在基线时记录了患者的年龄、性别、肿瘤组织学、部位、大小、首发症状和放疗治疗因素。在每次放疗和随访时记录肿瘤大小和与肿瘤相关的症状。结果基于意向治疗进行分析。
28 例患者共接受 31 次姑息性放疗，用于治疗皮肤基底细胞癌（5 例）或鳞状细胞癌（26 例）。21 例患者的 23 个肿瘤至少接受了一次随访，7 例患者的随访数据不完整。在最后一次随访时（中位数为 17 周），缓解率为 58.1%（完全缓解 15/31；部分缓解 3/31）。治疗后完全缓解与第 21 天肿瘤较小有关（P=0.0143）。有症状的部位缓解率为 61.3%（19/31）。未观察到严重的晚期毒性。
对于非黑素瘤皮肤癌患者，该姑息性治疗方案具有令人印象深刻的缓解率和有效的症状缓解作用。
