Department of Paediatric Orthopaedics, Children's University Hospital (UKBB) Basel.
Ann Oncol. 2011 Feb;22(2):458-67. doi: 10.1093/annonc/mdq394. Epub 2010 Aug 17.
Synovial sarcoma (SS) is a malignant soft tissue sarcoma with a poor prognosis because of late local recurrence and distant metastases. To our knowledge, no studies have minimum follow-up of 10 years that evaluate long-term outcomes for survivors.
Data on 62 patients who had been treated for SS from 1968 to 1999 were studied retrospectively in a multicenter study. Mean follow-up of living patients was 17.2 years and of dead patients 7.7 years.
Mean age at diagnosis was 35.4 years (range 6-82 years). Overall survival was 38.7%. The 5-year survival was 74.2%; 10-year survival was 61.2%; and 15-year survival was 46.5%. Fifteen patients (24%) died of disease after 10 years of follow-up. Local recurrence occurred after a mean of 3.6 years (range 0.5-14.9 years) and metastases at a mean of 5.7 years (range 0.5-16.3 years). Only four patients were treated technically correctly with a planned biopsy followed by a wide resection or amputation. Factors associated with significantly worse prognosis included larger tumor size, metastases at the time of diagnosis, high-grade histology, trunk-related disease, and lack of wide resection as primary surgical treatment.
In SS, metastases develop late with high mortality. Patients with SS should be followed for >10 years.
滑膜肉瘤（SS）是一种恶性软组织肉瘤，由于局部复发和远处转移较晚，预后较差。据我们所知，尚无研究对 10 年以上的长期生存者进行最低随访，以评估其长期结果。
对 1968 年至 1999 年期间接受 SS 治疗的 62 名患者的数据进行了回顾性多中心研究。存活患者的平均随访时间为 17.2 年，死亡患者的平均随访时间为 7.7 年。
诊断时的平均年龄为 35.4 岁（范围 6-82 岁）。总体生存率为 38.7%。5 年生存率为 74.2%；10 年生存率为 61.2%；15 年生存率为 46.5%。15 名患者（24%）在 10 年随访后死于疾病。局部复发的平均时间为 3.6 年（范围 0.5-14.9 年），转移的平均时间为 5.7 年（范围 0.5-16.3 年）。只有 4 名患者接受了计划活检后广泛切除或截肢的正确治疗。与预后显著相关的因素包括肿瘤较大、诊断时转移、高级别组织学、躯干相关疾病以及缺乏作为主要手术治疗的广泛切除。
在 SS 中，转移发生较晚，死亡率较高。SS 患者应随访>10 年。
