Department of Oncology and Neurosciences, G. d'Annunzio University, Chieti, Italy.
Cancer Prev Res (Phila). 2010 Oct;3(10):1284-91. doi: 10.1158/1940-6207.CAPR-09-0237. Epub 2010 Aug 17.
Transgenic adenocarcinoma of the mouse prostate (TRAMP) is a model for progressive prostate cancer that mirrors the stages of the human form. In this study, the effects of a diet enriched with processed whole tomatoes on survival, tumorigenesis, and progression of prostate cancer, and the antioxidant and inflammatory status of TRAMP mice were investigated. Tomato diet significantly increased overall survival (P < 0.01), delayed progression from prostatic intraepithelial neoplasia to adenocarcinoma, and decreased the incidence of poorly differentiated carcinoma. Biochemical data disclosed an increase in serum antioxidant activity and a reduction of serum inflammation/angiogenesis biomarkers of particular importance in prostate carcinogenesis.
转基因鼠前列腺癌（TRAMP）是一种进行性前列腺癌模型，与人类前列腺癌的发展阶段相似。本研究旨在探讨富含加工全番茄的饮食对 TRAMP 小鼠生存、肿瘤发生和进展以及抗氧化和炎症状态的影响。番茄饮食显著提高了整体存活率（P < 0.01），延缓了前列腺上皮内瘤变向腺癌的进展，并降低了低分化癌的发生率。生化数据显示血清抗氧化活性增加，血清炎症/血管生成生物标志物减少，这对前列腺癌的发生尤其重要。
