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1996-2005 年加拿大安大略省哮喘患病率和发病率趋势:一项人群研究。

Trends in asthma prevalence and incidence in Ontario, Canada, 1996-2005: a population study.

机构信息

Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5, Canada.

出版信息

Am J Epidemiol. 2010 Sep 15;172(6):728-36. doi: 10.1093/aje/kwq189. Epub 2010 Aug 17.

Abstract

In the 1980s and early 1990s, asthma prevalence increased significantly in most Westernized countries. In more recent years, asthma trends have been less clear, with some studies suggesting that they are still rising and others suggesting that they have stabilized or decreased. A population-based cohort study was conducted to estimate asthma prevalence and incidence trends in one large Canadian province, Ontario. All individuals with asthma living in Ontario, a province of Canada with a multicultural population of approximately 12 million, were identified in universal, population health administrative databases by using a validated health administrative case definition of asthma. Annual asthma prevalence, incidence, and all-cause mortality rates were estimated from 1996 to 2005. During this time, the prevalence of asthma increased by 70.5%. The age- and sex-standardized asthma prevalence increased from 8.5% in 1996 to 13.3% in 2005, a relative increase of 55.1% (P < 0.0001). Asthma incidence rates increased in children by 30.0% and were relatively stable in adults. Overall all-cause mortality decreased. Asthma prevalence in Ontario, Canada, has increased significantly. This is attributable, in part, to an increase in the incidence of asthma in children. Effective clinical and public health strategies are needed to prevent and manage asthma in the population.

摘要

在 20 世纪 80 年代和 90 年代初期,大多数西化国家的哮喘患病率显著上升。近年来,哮喘趋势不太明显,一些研究表明哮喘仍在上升,而另一些研究则表明哮喘已经稳定或下降。本研究开展了一项基于人群的队列研究,以评估加拿大安大略省一个大型省份的哮喘患病率和发病趋势。通过使用经过验证的哮喘行政病例定义,在通用的人群健康行政数据库中确定了安大略省所有患有哮喘的人群,安大略省是一个拥有约 1200 万多元文化人口的省份。1996 年至 2005 年期间,估计了哮喘的年患病率、发病率和全因死亡率。在此期间,哮喘患病率增加了 70.5%。年龄和性别标准化的哮喘患病率从 1996 年的 8.5%增加到 2005 年的 13.3%,相对增加了 55.1%(P < 0.0001)。儿童哮喘发病率增加了 30.0%,而成年人则相对稳定。总体全因死亡率下降。加拿大安大略省的哮喘患病率显著增加。这部分归因于儿童哮喘发病率的增加。需要有效的临床和公共卫生策略来预防和管理人群中的哮喘。

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