Sies H
Adv Exp Med Biol. 1977;94:561-6. doi: 10.1007/978-1-4684-8890-6_75.
Results obtained from a new approach of investigating O2 distribution in intact perfused liver under hypoxic conditions are presented. Based on the signals observed by organ absorbance spectrophotometry from two compartments with oxidases of markedly different O2 sensitivity, the mitochondria and the peroxisomes, a distribution between high O2 and zero O2 zones is postulated, an intermediate border zone of O2 concentrations between the K0,5 (O2) values being virtually absent (steep intercellular O2 gradients).
本文展示了在缺氧条件下研究完整灌注肝脏中氧气分布的新方法所获得的结果。基于通过器官吸光分光光度法在两个对氧气敏感度明显不同的隔室（线粒体和过氧化物酶体）中观察到的信号，推测存在高氧区和零氧区之间的分布，在K0.5（氧气）值之间几乎不存在氧气浓度的中间边界区（陡峭的细胞间氧气梯度）。
