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[S-1与吉西他滨联合化疗治疗不可切除胆管癌1例的疗效]

[Response in a case of inoperable bile duct cancer treated by combined chemotherapy of S-1 and gemcitabine].

作者信息

Akiyama Nobuhiro, Ayata Sakura, Maruyama Yuzuru, Tsukada Yoshihisa

机构信息

Dept. of Internal Medicene, Niigata Tokamachi Hospital.

出版信息

Gan To Kagaku Ryoho. 2010 Aug;37(8):1591-3.

Abstract

A 60-year-old male patient was diagnosed as bile duct cancer with left neck and abdominal para-aortic lymph node metastasis. He was treated by combined chemotherapy of S-1 and gemcitabine(GEM). S-1 (120 mg/day) was administered 14 days followed by 14 days rest as one course. GEM (1,000 mg/m2) was administered at 8 and 15 days after the start of S-1. Combined therapy could be continued, though S-1 and GEM were reduced for neutropemia. After 5 courses of treatment, CT and MRCP revealed a partial response. S-1/GEM combined therapy was effective for inoperable biliary tract carcinoma.

摘要

一名60岁男性患者被诊断为胆管癌伴左颈部及腹主动脉旁淋巴结转移。他接受了S-1与吉西他滨(GEM)的联合化疗。S-1(120毫克/天)给药14天,随后休息14天为一个疗程。GEM(1000毫克/平方米)在S-1开始后的第8天和第15天给药。尽管因中性粒细胞减少而减少了S-1和GEM的用量,但联合治疗仍可继续。经过5个疗程的治疗后,CT和磁共振胰胆管造影(MRCP)显示部分缓解。S-1/GEM联合治疗对无法手术的胆管癌有效。

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