Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls Universität Tübingen, Otfried-Mueller-Straße 10, Tübingen, Germany.
J Cereb Blood Flow Metab. 2010 Nov;30(11):1817-20. doi: 10.1038/jcbfm.2010.140. Epub 2010 Aug 18.
Vascular risk factors contribute to the progression of dementia in Alzheimer's disease (AD) and influence platelet activation. However, the degree of platelet activation as a possible underlying mechanism of this progression has not been studied till now. Significantly higher baseline expression of both platelet activation biomarkers, activated glycoprotein IIb-IIIa complex and P-selectin, was observed in patients with AD with fast cognitive decline compared with AD patients with slow cognitive decline during a 1-year follow-up period. These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients.
血管危险因素可导致阿尔茨海默病(AD)患者的认知功能恶化,并影响血小板的激活。然而,血小板激活在认知功能恶化中的作用机制尚不清楚。在 1 年的随访期内,与认知功能缓慢下降的 AD 患者相比,认知功能快速下降的 AD 患者血小板活化生物标志物(活化糖蛋白 IIb-IIIa 复合物和 P-选择素)的基线表达显著升高。这些结果表明,血小板激活可能是预测认知功能下降速度的预后生物标志物,也是 AD 患者的一个潜在的新治疗靶点。