Yalçin S Songül, Yurdakök Kadriye, Tezcan Ilhan, Tuncer Murat
Unit of Social Pediatrics, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2010 May-Jun;52(3):262-6.
To study the effect of glutamine supplementation on lymphocyte subpopulation counts in children with acute diarrhea, children aged 6-24 months were enrolled in a double-blind randomized study. Cases had received either 0.3 g/kg/day of glutamine or placebo orally for seven days. The counts of blood leukocytes, lymphocytes and lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD16+CD56+) were determined both on admission and seven days later using a flow cytometry. When adjusting for sex, current breastfeeding status, dehydration, and nutritional status of children, lymphocyte subpopulations did not differ significantly between the glutamine- and placebo-supplemented groups on the 7th day of intervention.
为研究补充谷氨酰胺对急性腹泻患儿淋巴细胞亚群计数的影响，选取6至24个月大的儿童参与一项双盲随机研究。病例组儿童口服0.3 g/kg/天的谷氨酰胺或安慰剂，为期7天。入院时及7天后，采用流式细胞术测定血白细胞、淋巴细胞及淋巴细胞亚群（CD3+、CD4+、CD8+、CD19+、CD16+CD56+）计数。在对儿童的性别、当前母乳喂养状况、脱水及营养状况进行校正后，干预第7天，补充谷氨酰胺组与补充安慰剂组的淋巴细胞亚群无显著差异。
