Wendling C, Dufour P, Oberling F
Service d'Onco-hématologie, CHU de Hautepierre, Strasbourg.
J Gynecol Obstet Biol Reprod (Paris). 1991;20(2):241-7.
Intra-peritoneal chemotherapy and immunotherapy are recent techniques for the treatment of tumours in the ovary. Chemotherapy is used more for the intra-peritoneal route. It is valuable because of the natural history of the disease and because of the pharmacological properties of many antimitotic drugs. Indwelling catheters have made this method easier and more acceptable to the patients. The drugs most used are cistplatinum and carboplatinum but mitoxantrone seems to be a very promising drug. The use of immunomodulators is just starting. Intra-peritoneal treatment should be at present reserved for small masses (less than 2 cm in diameter) whether used as a follow-up treatment or as a primary treatment in association with general chemotherapy.
腹腔内化疗和免疫疗法是治疗卵巢肿瘤的最新技术。化疗更多地用于腹腔途径。由于该疾病的自然病程以及许多抗有丝分裂药物的药理学特性，它很有价值。留置导管使这种方法对患者来说更容易且更易接受。最常用的药物是顺铂和卡铂，但米托蒽醌似乎是一种非常有前景的药物。免疫调节剂的使用才刚刚开始。目前，腹腔内治疗应仅用于小肿块（直径小于2厘米），无论是作为后续治疗还是与全身化疗联合作为初始治疗。
