Brahma 在精子发生和卵子发生过程中的甲基化模式：潜在意义。
Methylation patterns of Brahma during spermatogenesis and oogenesis: potential implications.
机构信息
Laboratory of Clinical and Developmental Genomics, Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20814, USA.
出版信息
Fertil Steril. 2011 Jan;95(1):382-4. doi: 10.1016/j.fertnstert.2010.05.064. Epub 2010 Aug 17.
To compare methylation profiles and expression levels of Brahma at different stages of spermatogenesis, and to identify the methylation pattern during oogenesis, we analyzed gene expression and methylation patterns in murine germ cells at various developmental stages. The methylation levels of CpG islands within Brahma increased during spermatogenesis and decreased during oogenesis. This change in methylation pattern correlates with the change in expression of Brahma during spermatogenesis. As the degree of methylation increases, the expression decreases. The change in methylation is opposite during oogenesis, which suggests opposite expression levels.
为了比较精子发生不同阶段的 Brahma 甲基化谱和表达水平，并鉴定卵子发生过程中的甲基化模式，我们分析了不同发育阶段的鼠类生殖细胞中的基因表达和甲基化模式。Brahma 内 CpG 岛的甲基化水平在精子发生过程中增加，在卵子发生过程中减少。这种甲基化模式的变化与精子发生过程中 Brahma 表达的变化相关。随着甲基化程度的增加，表达减少。在卵子发生过程中，甲基化的变化是相反的，这表明表达水平相反。
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