Laboratoire de Chimie Analytique - EA 4481, Univ. Lille Nord de France, F-59000 Lille, France.
J Pharm Biomed Anal. 2010 Dec 15;53(5):1267-71. doi: 10.1016/j.jpba.2010.07.023. Epub 2010 Jul 27.
Dissociation constants of benzimidazole derivatives have been determined using capillary zone electrophoresis (CZE). Since CZE is a separation method, high purity and known concentration for the samples is not necessary because only mobilities are measured. The precision of pK(a) measurements of seven compounds is useful to observe pK(a) shifts induced by chemical variations. Some of them were compared to potentiometry and spectroscopy experiments. Good correlated pK(a) values are observed between the three analytical techniques.
使用胶束电动毛细管色谱法（CZE）测定了苯并咪唑衍生物的离解常数。由于 CZE 是一种分离方法，因此不需要样品具有高纯度和已知浓度，因为只需测量迁移率。七种化合物的 pK（a）测量精度可用于观察化学变化引起的 pK（a）位移。其中一些与电位法和光谱实验进行了比较。在这三种分析技术之间观察到了良好相关的 pK（a）值。
