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B型流感嗜血杆菌结合疫苗在墨西哥儿童中诱导的血清学保护作用：是否需要加强剂量的疫苗？

Serological protection induced by Haemophilus influenzae Type B conjugate vaccine in Mexican children: is a booster dose of the vaccine needed?

作者信息

Rodriguez Romeo S, Mascarenas Cesar, Conde-Glez Carlos J, Inostroza Jaime, Villanueva Sonia, Velázquez María Elena, Sánchez-Alemán Miguel Angel, Echániz Gabriela

机构信息

National Institute of Public Health, Av. Universidad 655, Cuernavaca, Morelos, México.

出版信息

Clin Vaccine Immunol. 2010 Oct;17(10):1639-41. doi: 10.1128/CVI.00249-10. Epub 2010 Aug 18.

DOI:10.1128/CVI.00249-10
PMID:20719986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2953005/
Abstract

We determined the seroprevalence of protective antibodies against Hib in Mexican children under the age of five using a standardized enzyme-linked immunosorbent assay. Hib antibodies (≥ 0.15 μg/ml) were present in 95.34% (±1.14% [seroprevalence ± standard error]) of samples. Fewer children aged 30 to 47 months had protective Hib antibody levels (91.45% ± 2.60%) than children from 12 to 29 and 48 to 59 months (97.3% ± 1.34% and 97.44% ± 1.80%, respectively).

摘要

我们使用标准化酶联免疫吸附试验测定了墨西哥五岁以下儿童中抗b型流感嗜血杆菌保护性抗体的血清阳性率。95.34%（±1.14%[血清阳性率±标准误差]）的样本中存在抗b型流感嗜血杆菌抗体（≥0.15μg/ml）。30至47个月大的儿童中具有保护性抗b型流感嗜血杆菌抗体水平的比例（91.45%±2.60%）低于12至29个月以及48至59个月的儿童（分别为97.3%±1.34%和97.44%±1.80%）。

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