Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom.
J Nucl Med. 2010 Sep;51(9):1357-60. doi: 10.2967/jnumed.110.075903. Epub 2010 Aug 18.
Chronic obstructive pulmonary disease (COPD) patients exhibit increased cardiovascular risk, even after controlling for smoking. Inflammation may underlie this observation.
We measured vascular inflammation in both COPD patients and controls using (18)F-FDG PET/CT. Aortic inflammation was expressed as the target-to-background ratio (TBR) of the standardized uptake value in 7 COPD patients, 5 metabolic syndrome patients, and 7 ex-smokers.
Abdominal aortic mean TBR (+/-SD) was greater in COPD patients than in ex-smoker controls (1.60 +/- 0.13 vs. 1.34 +/- 0.15, P = 0.0001). Aortic arch and abdominal aorta mean TBRs were higher in metabolic syndrome patients than in COPD patients (aortic arch, 1.80 +/- 0.18 vs. 1.53 +/- 0.18, P = 0.001, and abdominal aorta, 1.71 +/- 0.14 vs. 1.60 +/- 0.13, P = 0.001).
COPD patients exhibited aortic inflammation that fell between the aortic inflammation exhibited by ex-smokers and that by metabolic syndrome patients. This may in part explain the increased risk of cardiovascular disease in COPD patients.
使用（18）F-FDG PET/CT 测量 COPD 患者和对照组的血管炎症。采用标准化摄取值的靶与背景比值（TBR）来表示 7 名 COPD 患者、5 名代谢综合征患者和 7 名戒烟者的主动脉炎症。
与戒烟者对照组相比，COPD 患者的腹主动脉平均 TBR（+/-SD）更高（1.60 +/- 0.13 比 1.34 +/- 0.15，P = 0.0001）。代谢综合征患者的主动脉弓和腹主动脉平均 TBR 高于 COPD 患者（主动脉弓，1.80 +/- 0.18 比 1.53 +/- 0.18，P = 0.001，腹主动脉，1.71 +/- 0.14 比 1.60 +/- 0.13，P = 0.001）。
COPD 患者的主动脉炎症处于戒烟者和代谢综合征患者之间。这可能部分解释了 COPD 患者心血管疾病风险增加的原因。
