STATinMED Research, Ann Arbor, MI, USA.
Am J Health Syst Pharm. 2010 Sep 1;67(17):1438-45. doi: 10.2146/ajhp090572.
The impact of postoperative venous thromboembolism (VTE) during initial hospitalization for total hip replacement (THR) or total knee replacement (TKR) surgery was assessed.
Using Medicare Provider Analysis and Review files, patients who underwent THR, TKR, or hip fracture surgery from 2005 to 2007 were identified using appropriate procedure codes from the International Classification of Diseases, 9th Revision, Clinical Modification. Medicare managed care patients were excluded from the study. Eligible patients were classified as having had deep venous thrombosis (DVT), pulmonary embolism (PE), DVT and PE, or no VTE during their initial hospitalization. Risk adjustment was performed using propensity score matching. Medicare cost, cost to beneficiaries, and cost to primary payers were analyzed to determine risk-adjusted differences in outcome measures, including mortality, rehospitalization, bleeding, length of stay, and total health care expenditures related to VTE events.
A total of 170,047 patients were identified. Postoperative VTE events occurred in 3,014 patients (1.77%) during their initial hospitalization. Risk-adjusted mortality rates were three to four times higher for patients with VTE compared with those without VTE. Patients with VTE were more likely to be rehospitalized and experience bleeding within 30 days. Risk-adjusted differences in annual mean cost, including Medicare cost and costs to beneficiaries and primary payers, were significantly greater for patients with VTE.
Patients who developed VTE after THR or TKR had a higher likelihood of mortality, bleeding, and rehospitalization; were hospitalized longer; and incurred higher costs to Medicare, Medicare beneficiaries, and private payers compared with patients without VTE.
评估全髋关节置换术(THR)或全膝关节置换术(TKR)术后初始住院期间静脉血栓栓塞症(VTE)的影响。
使用医疗保险提供者分析和审查文件,通过使用国际疾病分类第 9 版临床修订版的适当程序代码,确定 2005 年至 2007 年期间接受 THR、TKR 或髋部骨折手术的患者。从研究中排除了医疗保险管理式医疗患者。将符合条件的患者分为在初始住院期间患有深静脉血栓形成(DVT)、肺栓塞(PE)、DVT 和 PE 或无 VTE。使用倾向评分匹配进行风险调整。分析医疗保险费用、受益人费用和主要支付人费用,以确定与 VTE 事件相关的结局指标(包括死亡率、再住院率、出血、住院时间和总医疗保健支出)的风险调整差异。
共确定了 170047 名患者。在初始住院期间,3014 名患者(1.77%)发生术后 VTE 事件。与无 VTE 的患者相比,VTE 患者的死亡率高出三到四倍。VTE 患者在 30 天内再次住院和出血的可能性更高。VTE 患者的年度平均费用(包括医疗保险费用和受益人和主要支付人的费用)风险调整差异明显更大。
在 THR 或 TKR 后发生 VTE 的患者死亡、出血和再住院的可能性更高;住院时间更长;并给医疗保险、医疗保险受益人以及私人支付者带来更高的成本。