Division of Reproductive Endocrinology and Infertility, University of Texas at Southwestern Medical Center, Dallas, TX 75390, USA.
Reprod Sci. 2010 Nov;17(11):978-86. doi: 10.1177/1933719110379055. Epub 2010 Aug 18.
Traditionally, in women, only the theca cells in the ovary and the zona reticularis layer of the adrenal cortex are believed to synthesize androgens. Interestingly, their neighboring cell layers, the granulosa cells and the zona glomerulosa cells, respectively, do not produce androgens. Recent literature has highlighted the role of the activator protein (AP-1) transcription factor, c-Fos, in the dynamics of this structural and functional relationship. Differential expression of c-Fos is believed to result in distinct patterns of steroidogenesis among these compartments in both the ovary and the adrenal glands. Clinically, deficient c-Fos levels have been implicated in the pathogenesis of polycystic ovary syndrome (PCOS). In this review, we discuss the pivotal role of c-Fos in controlling the expression of CYP17 and hence androgen production in various organ systems throughout the human body.
传统上，人们认为只有卵巢中的卵泡膜细胞和肾上腺皮质的网状带层能够合成雄激素。有趣的是，它们相邻的细胞层，即颗粒细胞和球状带细胞，分别不产生雄激素。最近的文献强调了激活蛋白 (AP-1) 转录因子 c-Fos 在这种结构和功能关系动态中的作用。c-Fos 的差异表达被认为导致卵巢和肾上腺中这些隔室之间类固醇生成的不同模式。临床上，c-Fos 水平不足与多囊卵巢综合征 (PCOS) 的发病机制有关。在这篇综述中，我们讨论了 c-Fos 在控制 CYP17 的表达以及因此在人体各个器官系统中产生雄激素方面的关键作用。
