Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica, West Indies.
J Hum Hypertens. 2011 Jul;25(7):457-64. doi: 10.1038/jhh.2010.84. Epub 2010 Aug 19.
We hypothesized that maternal size, fetal size and childhood growth are associated with childhood blood pressure, left ventricular mass (LVM) and arterial stiffness. The Vulnerable Windows Cohort is a longitudinal study of 569 mothers and their offspring. Anthropometry was measured on each child at birth, at 6 weeks, once in 3 months upto 2 years and then every 6 months. Blood pressure and body composition were assessed in 185 children (age 11.5 years) and echocardiography performed. LVM was not associated with maternal size after adjustment for child's weight. LVM was significantly associated with faster growth in childhood and with current weight, fat mass and lean mass. Systolic blood pressure was not related to maternal, fetal or newborn anthropometry, but was positively associated with infant and childhood growth, as well as current body size and fat mass. The pulse pressure/stroke volume ratio (an index of arterial stiffness) was inversely associated with maternal size, placental volume at 20 weeks, fetal size at 35 weeks and childhood growth even after adjustment for current weight. In conclusion, LVM in childhood is positively associated with maternal height, child's current size and rate of growth. Arterial stiffness is inversely related to maternal, fetal and placental size as well as growth throughout childhood.
我们假设母亲的体型、胎儿的大小和儿童的生长与儿童的血压、左心室质量（LVM）和动脉僵硬有关。脆弱窗口队列是一项对 569 名母亲及其后代的纵向研究。在每个孩子出生时、6 周时、3 个月一次到 2 岁时，然后每 6 个月进行一次人体测量。在 185 名儿童（年龄 11.5 岁）中评估血压和身体成分，并进行超声心动图检查。在调整儿童体重后，LVM 与母亲体型无关。LVM 与儿童期更快的生长以及当前体重、脂肪量和瘦体重显著相关。收缩压与母亲、胎儿或新生儿的人体测量值无关，但与婴儿和儿童的生长以及当前的身体大小和脂肪量呈正相关。脉搏压/每搏量比（动脉僵硬的指标）与母亲体型、20 周时胎盘体积、35 周时胎儿大小以及儿童期生长呈负相关，即使在调整当前体重后也是如此。总之，儿童时期的 LVM 与母亲身高、儿童当前体型和生长速度呈正相关。动脉僵硬与母亲、胎儿和胎盘的大小以及整个儿童时期的生长呈负相关。
