College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 15;878(26):2461-4. doi: 10.1016/j.jchromb.2010.07.020. Epub 2010 Aug 3.
A novel beta-cyclodextrin (beta-CD) functionalized organic polymer monolith was prepared by covalently bonding ethylenediamine-beta-CD (EDA-beta-CD) to poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) monolith via ring opening reaction of epoxy groups. SEM characterization was performed to confirm the homogeneity of the monolithic polymer. The resulting monolith was then characterized by DSC and XPS elemental analysis to study the thermal stability of the monolith, and to prove the successful immobilization of beta-CD on the polymer substrate. The beta-CD ligand density of 0.68 mmol g(-1) was obtained for the modified monolith, indicating the high reactivity and efficiency of the EDA-beta-CD modifier. The ethylenediamine-beta-CD functionalized monoliths were used for the chiral separation of ibuprofen racemic mixture and showed promising results.
一种新型的β-环糊精（β-CD）功能化有机聚合物整体柱通过开环反应将乙二胺-β-CD（EDA-β-CD）键合到聚（甲基丙烯酸缩水甘油酯-乙二醇二甲基丙烯酸酯）（poly（GMA-co-EGDMA））整体柱上制备。SEM 表征用于确认整体聚合物的均一性。然后通过 DSC 和 XPS 元素分析对所得整体柱进行表征，以研究整体柱的热稳定性，并证明β-CD 成功固定在聚合物基质上。修饰后的整体柱的β-CD 配体密度为 0.68mmol/g（-1），表明 EDA-β-CD 修饰剂具有高反应性和效率。乙二胺-β-CD 功能化整体柱用于拆分布洛芬外消旋混合物，结果令人满意。
