Movement Disorders Centre, Toronto Western Hospital, Faculty of Medicine, University Health Network, University of Toronto, Ontario, Canada.
Can J Neurol Sci. 2010 Jul;37(4):478-81. doi: 10.1017/s0317167100010490.
A possible influence of estrogens on the dopaminergic system has been hypothesized and investigated by several studies, and fluctuations in motor symptoms related to the menstrual cycle have been reported in some movement disorders patients. We designed a survey to quantify how frequently female patients with various movement disorders are affected by this phenomenon and its impact on symptom severity.
A questionnaire was sent to 104 women between 18- and 60-years-old diagnosed with movement disorders and regularly followed at our centre.
From a total of 65 subjects who completed the questionnaire, 54 women reported the onset of their movement disorders before menopause. Twenty of them (37%) experienced changes in their movement disorders during the menstrual cycle. In particular, there was a significant worsening of symptom severity before (p=0.0005) and during menses (p=0.0004).
The possible role of such changes should be taken into account when evaluating the efficacy of various therapeutic interventions in movement disorder patients.
一些研究假设并探讨了雌激素对多巴胺能系统的可能影响，一些运动障碍患者报告了与月经周期相关的运动症状波动。我们设计了一项调查，以量化有多少患有各种运动障碍的女性患者受到这种现象的影响，以及其对症状严重程度的影响。
我们向在我们中心定期就诊的 104 名 18 至 60 岁的女性运动障碍患者发送了一份问卷。
在总共完成问卷的 65 名受试者中，有 54 名女性报告她们的运动障碍在绝经前发作。其中 20 人（37%）在月经周期中经历了运动障碍的变化。特别是，在月经前（p=0.0005）和月经期间（p=0.0004）症状严重程度显著恶化。
在评估各种治疗干预对运动障碍患者的疗效时，应考虑到这种变化的可能作用。
