Galgóczy L, Lukács Gyöngyi, Nyilasi Ildikó, Papp T, Vágvölgyi Cs
Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Acta Biol Hung. 2010 Sep;61(3):356-65. doi: 10.1556/ABiol.61.2010.3.11.
The in vitro antifungal activity of different statins and the combinations of the two most effective ones (fluvastatin and rosuvastatin) with amphotericin B were investigated in this study on 6 fungal isolates representing 4 clinically important genera, namely Absidia, Rhizomucor, Rhizopus and Syncephalastrum . The antifungal effects of statins revealed substantial differences. The synthetic statins proved to be more effective than the fungal metabolites. All investigated strains proved to be sensitive to fluvastatin. Fluvastatin and rosuvastatin acted synergistically and additively with amphotericin B in inhibiting the fungal growth in clinically available concentration ranges. Results suggest that statins combined with amphotericin B have a therapeutic potential against fungal infections caused by Zygomycetes species.
本研究考察了不同他汀类药物以及两种最有效的他汀类药物（氟伐他汀和瑞舒伐他汀）与两性霉素B联合使用时对6株分别代表4个临床重要属（即犁头霉属、根毛霉属、根霉属和共头霉属）的真菌分离株的体外抗真菌活性。他汀类药物的抗真菌作用显示出显著差异。合成他汀类药物被证明比真菌代谢产物更有效。所有研究菌株均被证明对氟伐他汀敏感。在临床可用浓度范围内，氟伐他汀和瑞舒伐他汀与两性霉素B联合使用时，在抑制真菌生长方面具有协同和相加作用。结果表明，他汀类药物与两性霉素B联合使用对由接合菌纲物种引起的真菌感染具有治疗潜力。
