• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Evidence against a protein in plasma that is a product of a factor XI mRNA splice variant missing exons 6 and 7.针对血浆中一种蛋白质的证据，该蛋白质是因子XI mRNA剪接变体缺失外显子6和7的产物。
Blood. 2010 Aug 19;116(7):1185-6; author reply 1186-7. doi: 10.1182/blood-2010-01-265702.
2
Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene.血小板因子XI的分子克隆，血浆因子XI基因的一种可变剪接产物
J Biol Chem. 1998 May 29;273(22):13787-93. doi: 10.1074/jbc.273.22.13787.
3
Factor XI messenger RNA in human platelets.人类血小板中的凝血因子XI信使核糖核酸
Blood. 1999 Nov 15;94(10):3397-404.
4
Real-time quantitative PCR analysis of factor XI mRNA variants in human platelets.人血小板中凝血因子XI mRNA变体的实时定量PCR分析
J Thromb Haemost. 2004 Oct;2(10):1713-9. doi: 10.1111/j.1538-7836.2004.00924.x.
5
Mutations in the factor XI gene.凝血因子XI基因的突变。
Am J Hematol. 2001 Jan;66(1):67. doi: 10.1002/1096-8652(200101)66:1<67::AID-AJH1014>3.0.CO;2-P.
6
Molecular characterization of two novel mutations causing factor XI deficiency: A splicing defect and a missense mutation responsible for a CRM+ defect.导致因子XI缺乏的两个新突变的分子特征：一个剪接缺陷和一个导致CRM+缺陷的错义突变。
Thromb Haemost. 2008 Mar;99(3):523-30. doi: 10.1160/TH07-12-0723.
7
Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein.凝血因子XI上H-激肽原结合位点的特征：凝血因子XI与血浆前激肽释放酶的比较。
J Biol Chem. 2002 Feb 15;277(7):4892-9. doi: 10.1074/jbc.M105221200. Epub 2001 Nov 30.
8
Platelet factor XI: intracellular localization and mRNA splicing following platelet activation.血小板因子XI：血小板激活后的细胞内定位及mRNA剪接
Blood Cells Mol Dis. 2018 Mar;69:30-37. doi: 10.1016/j.bcmd.2017.04.006. Epub 2017 Apr 21.
9
A type II mutation (Glu117stop), induction of allele-specific mRNA degradation and factor XI deficiency.
Haematologica. 2005 Dec;90(12):1716-8.
10
Novel splice variants of human ADAR2 mRNA: skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sites.人类ADAR2 mRNA的新型剪接变体：编码双链RNA结合结构域的外显子跳跃以及多个C端剪接位点。
Gene. 2005 Dec 19;363:193-201. doi: 10.1016/j.gene.2005.07.028. Epub 2005 Nov 16.

引用本文的文献

1
Factor XI and XII as antithrombotic targets.因子 XI 和因子 XII 作为抗血栓靶点。
Curr Opin Hematol. 2011 Sep;18(5):349-55. doi: 10.1097/MOH.0b013e3283497e61.

本文引用的文献

1
Molecular characterization of in-frame and out-of-frame alternative splicings in coagulation factor XI pre-mRNA.凝血因子 XI 前 mRNA 中框内和框外选择性剪接的分子特征。
Blood. 2010 Mar 11;115(10):2065-72. doi: 10.1182/blood-2009-09-245092. Epub 2009 Dec 30.
2
Factor XI contributes to thrombin generation in the absence of factor XII.在缺乏因子 XII 的情况下，因子 XI 有助于凝血酶的生成。
Blood. 2009 Jul 9;114(2):452-8. doi: 10.1182/blood-2009-02-203604. Epub 2009 Apr 7.
3
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI.通过抑制因子XI预防血管移植物闭塞和血栓相关凝血酶生成。
Blood. 2009 Jan 22;113(4):936-44. doi: 10.1182/blood-2008-06-163675. Epub 2008 Oct 22.
4
Molecular modeling of the prekallikrein structure provides insights into high-molecular-weight kininogen binding and zymogen activation.前激肽释放酶结构的分子建模为高分子量激肽原结合和酶原激活提供了见解。
J Thromb Haemost. 2007 Dec;5(12):2461-6. doi: 10.1111/j.1538-7836.2007.02792.x. Epub 2007 Oct 8.
5
Crystal structure of the factor XI zymogen reveals a pathway for transactivation.凝血因子XI酶原的晶体结构揭示了反式激活途径。
Nat Struct Mol Biol. 2006 Jun;13(6):557-8. doi: 10.1038/nsmb1095. Epub 2006 May 14.
6
Identification of amino acids in the factor XI apple 3 domain required for activation of factor IX.
J Biol Chem. 1999 Dec 17;274(51):36373-8. doi: 10.1074/jbc.274.51.36373.
7
Identification of a factor IX binding site on the third apple domain of activated factor XI.活化因子XI第三个苹果结构域上因子IX结合位点的鉴定。
J Biol Chem. 1996 Nov 15;271(46):29023-8. doi: 10.1074/jbc.271.46.29023.
8
Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.人凝血因子XI的氨基酸序列，该凝血因子具有四个串联重复序列，与血浆前激肽释放酶高度同源。
Biochemistry. 1986 May 6;25(9):2417-24. doi: 10.1021/bi00357a018.
9
Organization of the gene for human factor XI.
Biochemistry. 1987 Nov 17;26(23):7221-8. doi: 10.1021/bi00397a004.
10
Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII.
J Biol Chem. 1977 Sep 25;252(18):6432-7.

Evidence against a protein in plasma that is a product of a factor XI mRNA splice variant missing exons 6 and 7.

作者信息

Gailani David, Sun Mao-Fu, Cheng Qiufang, Matafonov Anton, Tucker Erik I, Gruber Andras, Emsley Jonas

出版信息

Blood. 2010 Aug 19;116(7):1185-6; author reply 1186-7. doi: 10.1182/blood-2010-01-265702.

DOI:10.1182/blood-2010-01-265702
PMID:20724549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2938133/
Abstract
摘要