Department of Medicine, Cooper University Hospital, Camden, NJ 08103, USA.
Am J Ther. 2012 Jul;19(4):e136-8. doi: 10.1097/MJT.0b013e3181ed838c.
Drug-induced lupus erythematosus differs in its manifestation from drug-induced vasculitis. The former is associated with characteristic symptoms that improve following discontinuation, whereas the latter is predominantly an antineutrophil cytoplasmic antibody (ANCA) positive small vessel vasculitis involving the kidneys, skin, and lungs. We present a case of advanced disease in an elderly Caucasian woman requiring corticosteroids, and immunosuppressive therapy, who was on hydralazine for >2 years.
药物性红斑狼疮的表现与药物性血管炎不同。前者与特征性症状相关,停药后症状改善,而后者主要为抗中性粒细胞胞质抗体(ANCA)阳性的小血管血管炎,累及肾脏、皮肤和肺部。我们报告了一例高龄白人女性的晚期疾病,需要皮质类固醇和免疫抑制治疗,她使用肼屈嗪 >2 年。