Children's Hospital Boston, Division of Adolescent Medicine, 333 Longwood Avenue, Boston, MA 02115, USA.
Curr Opin Obstet Gynecol. 2010 Oct;22(5):363-8. doi: 10.1097/GCO.0b013e32833e4a35.
We present an update on hormonal replacement therapy (HRT) for adolescents and young women with deficiencies of pubertal hormones.
Although the optimal HRT regimen remains unclear and data in adolescents are limited, this review will update clinicians regarding the current issues facing them as they care for adolescents with an insufficiency of sex steroids. We suggest a stepwise approach to HRT, with a gradual increase in dosing. Recent evidence regarding transdermal versus oral preparations, the effects of HRT on skeletal health, and newer methods for providing HRT are reviewed.
HRT is needed by many adolescents for varied reasons, all with hypogonadism as a common endpoint. Despite the large numbers of patients for whom HRT is prescribed, little prospective data exist to aid clinicians in making evidence-based decisions as to the optimal treatment regimens. Research consortia should be established to allow investigation of these important questions, and to allow clinicians to make the best possible healthcare decisions as they care for these adolescents and young women.
我们介绍了青春期和年轻女性因青春期激素缺乏而进行激素替代治疗（HRT）的最新进展。
尽管最佳 HRT 方案仍不清楚，且青少年的数据有限，但本篇综述将为临床医生提供关于治疗青春期性腺功能减退症患者的最新信息。我们建议采用逐步增加剂量的 HRT 方法。本文还综述了最近关于经皮与口服制剂、HRT 对骨骼健康的影响以及提供 HRT 的新方法的证据。
许多青春期患者出于各种原因需要 HRT，所有患者都有共同的终点——性腺功能减退症。尽管有大量患者需要 HRT，但几乎没有前瞻性数据可以帮助临床医生根据最佳治疗方案做出基于证据的决策。应建立研究联盟，以研究这些重要问题，并帮助临床医生在照顾这些青少年和年轻女性时做出最佳的医疗保健决策。
