Department of Ophthalmology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.
J Neuroophthalmol. 2010 Sep;30(3):252-4. doi: 10.1097/WNO.0b013e3181e22ef0.
A 70-year-old woman developed progressive visual loss with compromised visual acuity and visual fields, cells in the anterior chamber and vitreous, attenuated retinal arterioles, and macular edema. She had undergone right oophorectomy and partial salpingectomy nearly 50 years earlier. Full-field and multifocal electroretinography showed waveforms of markedly attenuated amplitudes, findings consistent with cancer-associated retinopathy (CAR). Positron emission tomography revealed a nodule in the anterior wall of a right hydrosalpinx. Total laparoscopic hysterectomy yielded a neuroendocrine fallopian tube malignancy. She underwent partial treatment with paclitaxel and carboplatin that was aborted because of the development of herpes zoster infection. At 15 months following diagnosis, her ophthalmic status was stable. This is the first report of CAR in neuroendocrine carcinoma of the fallopian tube.
一位 70 岁女性出现进行性视力丧失,伴有视力和视野受损、前房和玻璃体细胞、视网膜小动脉减弱以及黄斑水肿。她在近 50 年前接受了右侧卵巢切除术和部分输卵管切除术。全视野和多焦视网膜电图显示明显减弱的波幅,与癌症相关性视网膜病变(CAR)相符。正电子发射断层扫描显示右侧输卵管积水前壁有一个结节。全腹腔镜子宫切除术显示出一种神经内分泌输卵管恶性肿瘤。她接受了紫杉醇和顺铂的部分治疗,但因带状疱疹感染的发展而中断。在诊断后 15 个月,她的眼部状况稳定。这是输卵管神经内分泌癌合并 CAR 的首例报告。