Nezami Behtash Ghazi, Srinivasan Shanthi
Division of Digestive Diseases, Emory University School of Medicine and VAMC, Whitehead Research Building, Suite 246, 615 Michael St., Atlanta, GA 30307, USA.
Curr Gastroenterol Rep. 2010 Oct;12(5):358-65. doi: 10.1007/s11894-010-0129-9.
The digestive system is endowed with its own, local nervous system, referred to as the enteric nervous system (ENS). Given the varied functions of small intestine, its ENS has developed individualized characteristics relating to motility, secretion, digestion, and inflammation. The ENS regulates the major enteric processes such as immune response, detecting nutrients, motility, microvascular circulation, intestinal barrier function, and epithelial secretion of fluids, ions, and bioactive peptides. Remarkable progress has been made in understanding the signaling pathways in this complex system and how they work. In this article, we focus on recent advances that have led to new insights into small intestinal ENS function and the development of new therapies.
消化系统拥有自身的局部神经系统，即肠神经系统（ENS）。鉴于小肠功能多样，其肠神经系统在运动、分泌、消化和炎症方面形成了个体化特征。肠神经系统调节主要的肠道过程，如免疫反应、检测营养物质、运动、微血管循环、肠道屏障功能以及上皮细胞对液体、离子和生物活性肽的分泌。在理解这个复杂系统中的信号通路及其工作方式方面已经取得了显著进展。在本文中，我们重点关注那些为小肠肠神经系统功能带来新见解以及新疗法发展的最新进展。
