Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Org Lett. 2010 Sep 17;12(18):4034-7. doi: 10.1021/ol101631e.
A convergent and stereoselective synthesis of 2,5-disubstituted 3-hydroxypyrrolidines has been developed that involves reductive annulation of β-iminochlorohydrins, which are readily available from β-ketochlorohydrins, and provides rapid access to a variety of 2,5-syn-pyrrolidines. Application of this process to the concise (three-step) synthesis of the fungal metabolite (+)-preussin and analogues of this substance is reported.
已开发出一种 2,5-二取代 3-羟基吡咯烷的收敛和立体选择性合成方法，该方法涉及β-亚氨基氯醇的还原环化，β-酮氯醇很容易得到，并且可以快速获得各种 2,5-顺式吡咯烷。该方法已应用于真菌代谢产物（+）-普雷辛及其类似物的简洁（三步）合成。
