酰胺参与的溴环丙烷的亲核取代反应，可得到构象受限制的β-氨基酸衍生物。
Formal nucleophilic substitution of bromocyclopropanes with amides en route to conformationally constrained β-amino acid derivatives.
机构信息
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-75832, USA.
出版信息
Org Lett. 2010 Sep 17;12(18):3968-71. doi: 10.1021/ol101228k.
PMID:20726591
Abstract
A chemo- and diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with secondary amides is described. This method allows for convergent and highly selective synthesis of trans-β-aminocyclopropane carboxylic acid derivatives.
摘要
本文描述了一种对 2-溴环丙基甲酰胺进行化学选择性和非对映选择性亲核取代的方法。该方法可用于反式-β-氨基环丙烷羧酸衍生物的高收率和高选择性的合成。
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