Department of Food Science and Technology, Chung-Ang University, Anseong, Republic of Korea.
J Med Food. 2010 Oct;13(5):1263-72. doi: 10.1089/jmf.2010.1015.
This study examined the effects of high dietary lard on the cardiovascular system responsible for regulating blood pressure in the spontaneously hypertensive rat (SHR), a model of essential human hypertension. The fat contents were 4.5% of diet weight for control diet and 20% for high-lard diet, respectively. Four-week-old male SHR animals were fed the diets for 9 weeks. After 9 weeks of feeding, the cardiovascular responses to the intravenous administration of vasoactive drugs were determined in conscious SHR animals. The pressor responses elicited by the α₁-adrenoceptor agonist phenylephrine were diminished in high-lard-fed SHR animals. The depressor responses elicited by the ß-adrenoceptor agonist isoproterenol were equivalent in the high-lard-fed SHR and control SHR groups. The depressor responses elicited by the nitric oxide donor sodium nitroprusside were equivalent in both dietary groups. The depressor responses elicited by the endothelium-dependent agonist acetylcholine were diminished in high-lard-fed SHR animals. Baroreceptor reflex-mediated changes in heart rates in response to changes in mean arterial blood pressure (MAP) elicited by phenylephrine and sodium nitroprusside were diminished in the high-lard-fed SHR group. Despite the diminished endothelium-dependent vasodilation and impaired baroreflex function, resting MAP values were similar in both dietary groups. These findings suggest that high dietary lard does not exacerbate hypertension in the SHR model.
这项研究探讨了高膳食猪油对心血管系统的影响，心血管系统负责调节自发性高血压大鼠（SHR）的血压，SHR 是人类原发性高血压的模型。对照饮食中的脂肪含量为饮食重量的 4.5%，高猪油饮食中的脂肪含量为 20%。4 周龄雄性 SHR 动物分别用上述两种饮食喂养 9 周。喂养 9 周后，在清醒的 SHR 动物中测定静脉给予血管活性药物后的心血管反应。α₁-肾上腺素能受体激动剂苯肾上腺素引起的升压反应在高猪油喂养的 SHR 动物中减弱。β-肾上腺素能受体激动剂异丙肾上腺素引起的降压反应在高猪油喂养的 SHR 和对照 SHR 组中相当。一氧化氮供体硝普钠引起的降压反应在两组饮食中相当。内皮依赖性激动剂乙酰胆碱引起的降压反应在高猪油喂养的 SHR 动物中减弱。苯肾上腺素和硝普钠引起的平均动脉血压（MAP）变化引起的心率的压力感受器反射介导的变化在高猪油喂养的 SHR 组中减弱。尽管内皮依赖性血管舒张减弱和压力反射功能受损，但两组饮食的静息 MAP 值相似。这些发现表明，高膳食猪油不会使 SHR 模型中的高血压恶化。
