Tan Belinda H, Barry Catherine I, Wick Mark R, White Kevin P, Brown Jeffrey G, Lee Abigail, Litchfield Amy H, Lener Elizabeth V, Shitabata Paul K
Division of Dermatology, Harbor-UCLA Medical Center, Torrance, CA, USA.
J Cutan Pathol. 2011 Jan;38(1):43-8. doi: 10.1111/j.1600-0560.2010.01608.x. Epub 2010 Aug 18.
Multicentric reticulohistiocytosis (MR) is a rare non-Langerhans histiocytosis that is characterized by cutaneous nodules and severe destructive arthritis. Although 25-30% of reported cases have been associated with internal malignancies, the pathophysiology of MR is unknown. Herein, we report two cases of MR that were associated with urologic neoplasms. Because the tumor suppressor gene p53 may play a role in the biology of other histiocytoses, we investigated its p53 immunoexpression in these two cases. Both cases were positive immunohistochemically, but it remains to be seen whether this finding is truly important in the pathogenesis of MR associated with underlying visceral neoplasms.
多中心网状组织细胞增多症（MR）是一种罕见的非朗格汉斯组织细胞增多症，其特征为皮肤结节和严重的破坏性关节炎。尽管报告病例中有25% - 30%与内脏恶性肿瘤相关，但MR的病理生理学尚不清楚。在此，我们报告两例与泌尿系统肿瘤相关的MR病例。由于肿瘤抑制基因p53可能在其他组织细胞增多症的生物学过程中起作用，我们研究了这两例病例中p53的免疫表达情况。两例病例免疫组化均呈阳性，但这一发现对于与潜在内脏肿瘤相关的MR发病机制是否真的重要仍有待观察。
