Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan.
Gen Comp Endocrinol. 2010 Nov 1;169(2):144-50. doi: 10.1016/j.ygcen.2010.08.006. Epub 2010 Aug 18.
Neuromedin B (NMB) and neuromedin C (NMC) are homologs of bombesin and are distributed throughout both the brain and gastrointestinal tract. The physiological roles of these bombesin-like peptides in chicks (Gallus gallus) have not been documented. Therefore, the purpose of the present study was to measure the effects of these bombesin-like peptides on food intake, crop-emptying rate and body temperature in chicks, and then to compare these effects with those of bombesin. Intracerebroventricular (ICV, 5 nmol) and intraperitoneal (IP, 300 nmol/kg) injections of NMB, NMC, and bombesin significantly decreased food deprivation-induced food intake. When ICV injected (5 nmol), all three peptides significantly reduced crop-emptying rate. IP injection of NMC and bombesin (300 nmol/kg) also reduced crop-emptying rate while NMB did not. The magnitude of food intake suppression and crop-emptying rate reduction were greater for bombesin than NMB and NMC. ICV and IP injections of NMB, NMC and bombesin did not affect cloacal temperature. In sum, the present study suggests that central and peripheral NMB and NMC are associated with reduced food intake and crop-emptying of chicks, but these effects are weaker than those of bombesin.
神经调节素 B（NMB）和神经调节素 C（NMC）是蛙皮素的同源物，分布于大脑和胃肠道中。这些类似蛙皮素的肽类在小鸡（Gallus gallus）中的生理作用尚未得到证实。因此，本研究的目的是测量这些类似蛙皮素的肽类对小鸡摄食、嗉囊排空率和体温的影响，并将这些影响与蛙皮素的影响进行比较。脑室（ICV，5 nmol）和腹腔内（IP，300 nmol/kg）注射 NMB、NMC 和蛙皮素均可显著减少饥饿诱导的摄食量。当 ICV 注射（5 nmol）时，这三种肽均显著降低了嗉囊排空率。IP 注射 NMC 和蛙皮素（300 nmol/kg）也降低了嗉囊排空率，而 NMB 则没有。抑制摄食和减少嗉囊排空率的作用强度，蛙皮素强于 NMB 和 NMC。NMB、NMC 和蛙皮素的 ICV 和 IP 注射均不影响泄殖腔温度。总之，本研究表明，中枢和外周 NMB 和 NMC 与小鸡摄食减少和嗉囊排空有关，但这些作用比蛙皮素弱。
