替加环素联合庆大霉素对生物膜形成的金黄色葡萄球菌的体外活性。
In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus.
机构信息
Department of Pharmacy Practice, University of Rhode Island, Veterans Affairs Medical Center (151), Providence, RI 02908, USA.
出版信息
Diagn Microbiol Infect Dis. 2010 Sep;68(1):1-6. doi: 10.1016/j.diagmicrobio.2010.04.011.
We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 +/- 0.17 log(10) CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 +/- 0.26 log(10) CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus.
我们在体外药效动力学模型中研究了替加环素联合庆大霉素治疗生物膜形成的耐甲氧西林金黄色葡萄球菌的活性。替加环素单独治疗在 48 小时内表现出抑菌活性（-0.24 +/- 0.17 log(10) CFU/mL），而替加环素联合庆大霉素在 48 小时内表现出显著的杀菌活性（P < 0.002）（-3.66 +/- 0.26 log(10) CFU/mL）。庆大霉素的加入显著提高了替加环素在生物膜形成的金黄色葡萄球菌中的杀菌活性。
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