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[游离皮瓣头颈部重建失败:预测因素与处理]

[Free-flap head and neck reconstruction failures: predictive factors and management].

作者信息

David S, Dassonville O, Poissonnet G, Chamorey E, Vallicioni J, Demard F, Médard de Chardon V, Santini J, Bozec A

机构信息

Service de chirurgie plastique, esthétique et reconstructrice et de chirurgie de la main, hôpital Saint-Roch, Nice, France.

出版信息

Ann Chir Plast Esthet. 2011 Aug;56(4):308-14. doi: 10.1016/j.anplas.2010.07.004. Epub 2010 Aug 21.

DOI:10.1016/j.anplas.2010.07.004
PMID:20728259
Abstract

BACKGROUND

Failure after head and neck reconstruction using free flap are rare but their management remains a challenging problem. The purpose of this study was to analyze the causes and the subsequent treatment of free-flap failure in head and neck reconstruction.

PATIENTS AND METHODS

A retrospective review of patients who had undergone free flap transfer between 2000 and 2007 was performed in our center. Data were collected from computerized medical record to determine patient and tumor characteristics, as well as their treatment. Moreover, a univariate analysis was performed to determine factors associated with free flap failure.

RESULTS

Three hundred and twelve patients had a free flap transfer after head and neck cancer resection. A total of 22 failures (7%) were encountered. Previous surgery for head and neck cancer (p=0.02), surgery after cancer recurrence (p=0.02) and reconstructions after circular pharyngolaryngectomy (p=0.008) were significantly associated with free-flap failure. A second free-flap was performed in 12 patients and the overall success rate of the repeated free flap was 92 percent (11 of 12 patients).

CONCLUSION

After a free flap failure, surgeons should determine subsequent treatments after a reconsideration of the need of a second free flap, an analysis of the cause of the first flap failure and an evaluation of local and general conditions. In selected patients, second free flap has a high success rate.

摘要

背景

头颈部游离皮瓣重建术后失败的情况较为罕见,但处理起来仍然是一个具有挑战性的问题。本研究的目的是分析头颈部重建中游离皮瓣失败的原因及后续治疗方法。

患者与方法

对2000年至2007年间在本中心接受游离皮瓣移植的患者进行回顾性研究。从计算机化病历中收集数据,以确定患者和肿瘤的特征以及他们的治疗情况。此外,进行单因素分析以确定与游离皮瓣失败相关的因素。

结果

312例患者在头颈部癌切除术后接受了游离皮瓣移植。共出现22例失败(7%)。既往有头颈部癌手术史(p=0.02)、癌症复发后手术(p=0.02)以及环状咽喉切除术后重建(p=0.008)与游离皮瓣失败显著相关。12例患者进行了第二次游离皮瓣手术,重复游离皮瓣的总体成功率为92%(12例患者中的11例)。

结论

游离皮瓣失败后,外科医生应在重新考虑是否需要进行第二次游离皮瓣、分析首次皮瓣失败的原因以及评估局部和全身状况后确定后续治疗方案。在选定的患者中,第二次游离皮瓣成功率较高。

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Otolaryngol Head Neck Surg. 2022 Aug;167(2):224-235. doi: 10.1177/01945998211044683. Epub 2021 Sep 7.
2
Oral and Oropharyngeal Reconstruction with a Free Flap.游离皮瓣用于口腔及口咽重建。
Arch Craniofac Surg. 2016 Jun;17(2):45-50. doi: 10.7181/acfs.2016.17.2.45. Epub 2016 Jun 21.
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Impact of patient comorbidities on head and neck microvascular reconstruction. A report on 423 cases.
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Eur Arch Otorhinolaryngol. 2013 May;270(5):1741-6. doi: 10.1007/s00405-012-2224-z. Epub 2012 Oct 19.