Cerone G, Ruggieri S, Agnoli A
Acta Neurol Belg. 1977 Jul-Aug;77(4):213-29.
In the Parkinsonian syndrome tremor is the symptom which still eludes pharmacological therapy. The authors report the results of nine cases of Parkinsonian tremor in which agonist and antagonist drugs acting on the receptors were employed. These were dopaminergics, acetylcholinergics, serotoninergics, histaminics, and alpha- and beta-adrenergics. The data obtained demonstrate the involvement of all the neurotransmitters studied, some directly through quantitative modifications, others indirectly through their involvement in reciprocal functional equilibria. A sytem of equilibria is hypothesized in which the histamine: serotonin ratio is given greater emphasis. (Acta neurol belg., 1977, 77, 213-229).
在帕金森综合征中，震颤是仍无法通过药物治疗缓解的症状。作者报告了9例帕金森震颤患者的治疗结果，这些患者使用了作用于受体的激动剂和拮抗剂药物。这些药物包括多巴胺能药物、乙酰胆碱能药物、5-羟色胺能药物、组胺能药物以及α和β肾上腺素能药物。所获得的数据表明，所有研究的神经递质都参与其中，一些是通过定量改变直接参与，另一些则是通过它们参与相互功能平衡间接参与。假设存在一个平衡系统，其中组胺与5-羟色胺的比例受到更大重视。（《比利时神经学学报》，1977年，77卷，213 - 229页）
