Division of Trauma Surgery and Critical Care, University of Southern California, LAC+USC Medical Center, Los Angeles, CA, USA.
J Am Coll Surg. 2010 Oct;211(4):450-5. doi: 10.1016/j.jamcollsurg.2010.06.012. Epub 2010 Aug 21.
The persistent shortage of transplantable organs remains a critical issue around the world. The purpose of this study was to investigate outcomes, including organ procurement, in trauma patients undergoing resuscitative emergency department thoracotomy (EDT). Our hypothesis was that potential organ donor rescue is one of the important outcomes after traumatic arrest and EDT.
Retrospective study at Los Angeles County and University of Southern California Medical Center. Patients undergoing resuscitative EDT from January 1, 2006 through June 30, 2009 were analyzed. Primary outcomes measures included survival. Secondary outcomes included organ donation and the brain-dead potential organ donor.
During the 42-month study period, a total of 263 patients underwent EDT. Return of a pulse was achieved in 85 patients (32.3%). Of those patients, 37 (43.5%) subsequently died in the operating room and 48 (56.5%) survived to the surgical intensive care unit. Overall, 5 patients (1.9%) survived to discharge and 11 patients (4.2%) became potential organ donors. Five of the 11 potential organ donors had sustained a blunt mechanism injury. Of the 11 potential organ donors, 8 did not donate: 4 families declined consent, 3 because of poor organ function, and 1 expired due to cardiopulmonary collapse. Eventually 11 organs (6 kidneys, 2 livers, 2 pancreases, and 1 small bowel) were harvested from 3 donors. Two of the 3 donors had sustained blunt injury and 1 penetrating mechanism of injury.
Procurement of organs is one of the tangible outcomes after EDT. These organs have the potential to alter the survival and quality of life of more recipients than the number of survivors of the procedure itself.
全球范围内,可供移植的器官持续短缺仍是一个严峻的问题。本研究旨在探讨创伤患者接受抢救性急诊开胸术(EDT)后的结局,包括器官获取。我们的假设是创伤性心跳骤停后和 EDT 后潜在的器官捐献者抢救是重要结局之一。
这是洛杉矶县和南加州大学医疗中心的回顾性研究。分析了 2006 年 1 月 1 日至 2009 年 6 月 30 日期间行抢救性 EDT 的患者。主要结局指标包括生存。次要结局指标包括器官捐献和脑死亡潜在器官捐献者。
在 42 个月的研究期间,共有 263 例患者接受了 EDT。85 例(32.3%)患者恢复了脉搏。其中 37 例(43.5%)随后在手术室死亡,48 例(56.5%)存活至外科重症监护病房。总体而言,有 5 例(1.9%)患者存活出院,11 例(4.2%)成为潜在器官捐献者。11 例潜在器官捐献者中有 5 例遭受钝性损伤机制。在 11 例潜在器官捐献者中,8 例未捐献:4 例家属拒绝同意,3 例因器官功能不良,1 例因心肺崩溃而死亡。最终有 3 名供者捐献了 11 个器官(6 个肾脏、2 个肝脏、2 个胰腺和 1 个小肠)。3 名供者中有 2 名遭受钝性损伤,1 名遭受穿透性损伤机制。
EDT 后获取器官是有形的结局之一。这些器官有可能改变比手术本身存活者更多受者的生存和生活质量。