Yildirim Rahsan, Bilen Yusuf, Keles Mustafa, Uyanik Abdullah, Albayrak Fatih, Erdem Fuat, Kiki Ilhami, Cetinkaya Ramazan, Gundogdu Mehmet
Department of Hematology, Ataturk University, School of Medicine, Erzurum, Turkey.
Transfus Apher Sci. 2010 Oct;43(2):159-62. doi: 10.1016/j.transci.2010.07.007. Epub 2010 Aug 21.
We aimed to describe the characteristics, treatment regime, and 6-month all-cause mortality of thrombotic thrombocytopenic purpura (TTP) patients treated with total plasma exchange in the our clinic. Thirteen patients were included in the study. Mortality rates of TTP have improved over the last three decades but they are still too high according to modern therapy expectations. Etiology directed treatment should be added to total plasma exchange in secondary TTP cases. Based on TTPs' immunologic etiology, immune modulator and immune suppressor agents have been applied together with total plasma exchange, but mostly in anecdotal case reports or with questionable responses.
我们旨在描述在我们诊所接受全血浆置换治疗的血栓性血小板减少性紫癜（TTP）患者的特征、治疗方案以及6个月的全因死亡率。该研究纳入了13名患者。在过去三十年中，TTP的死亡率有所改善，但按照现代治疗的预期，其死亡率仍然过高。在继发性TTP病例中，应在全血浆置换的基础上增加针对病因的治疗。基于TTP的免疫病因，免疫调节剂和免疫抑制剂已与全血浆置换联合应用，但大多仅见于个案报道或疗效存疑。
