Townsend Raymond R, Roman Mary J, Najjar Samer S, Cockcroft John R, Feig Peter U, Stockbridge Norman L
J Am Soc Hypertens. 2010 Sep-Oct;4(5):211-4. doi: 10.1016/j.jash.2010.07.002. Epub 2010 Aug 21.
Over a century of experience with brachial blood pressure has produced a substantial amount of information on the role of blood pressure as a factor in heart disease, stroke and kidney failure. Successful interventions lowering blood pressure and reducing damage to vital organs testify further to the importance of this vital sign. In recent years attempts to probe deeper into the value of knowledge of blood pressure levels closer to the heart (central blood pressures) suggest that noninvasive measurement of central aortic blood pressure may improve further efforts directed at both understanding drug benefit and uncovering potential drug safety issues. This commentary is a summary of a one-day meeting with the FDA in which the role of central blood pressure measurements as an adjunct to drug efficacy and safety were addressed.
一个多世纪以来对肱动脉血压的研究产生了大量关于血压在心脏病、中风和肾衰竭中所起作用的信息。成功降低血压并减少对重要器官损害的干预措施进一步证明了这一生命体征的重要性。近年来，人们试图更深入地探究更接近心脏的血压水平（中心血压）的价值，这表明无创测量中心主动脉血压可能会进一步有助于理解药物疗效和发现潜在药物安全问题。本评论是与美国食品药品监督管理局（FDA）举行的为期一天会议的总结，会议讨论了中心血压测量作为药物疗效和安全性辅助手段的作用。
