Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India.
IEEE Trans Nanobioscience. 2010 Dec;9(4):225-31. doi: 10.1109/TNB.2010.2061863. Epub 2010 Aug 19.
All cells receive and respond to signals from their environment, whether they live freely or are part of a tissue. Feedback loops are one among the interactions in signal-transduction cascades, in which the information from the downstream components is sent back to the upstream components of the system. Crosstalks between signal-transduction cascades are able to combine the information's received and processed to trigger the appropriate response. To understand how signaling networks make decisions, the dynamic interactions of proteins in the signal-transduction cascades are important rather than just creating static maps of pathways. Based on reaction kinetics, we have developed mathematical models to predict and analyze the impacts of the feedback loops in JNK cascades and the crosstalks between JNK and P38 kinase cascades. Feedback loops in JNK cascades and crosstalks between JNK and P38 kinase cascades plays the complementary roles in making the impacts on the activation of JNK and P38 kinases. JNK and P38 kinase cascades with feedbacks and crosstalks is a robust system.
所有细胞都会接收和响应来自其环境的信号，无论它们是自由生活的还是组织的一部分。反馈回路是信号转导级联中的相互作用之一，其中来自下游组件的信息被发送回系统的上游组件。信号转导级联之间的串扰能够组合接收和处理的信息，以触发适当的响应。为了了解信号网络如何做出决策，信号转导级联中蛋白质的动态相互作用比仅仅创建途径的静态图谱更为重要。基于反应动力学，我们已经开发了数学模型来预测和分析 JNK 级联中的反馈回路以及 JNK 和 P38 激酶级联之间的串扰对 JNK 和 P38 激酶激活的影响。JNK 级联中的反馈回路和 JNK 和 P38 激酶级联之间的串扰在对 JNK 和 P38 激酶的激活产生影响方面起着互补作用。具有反馈和串扰的 JNK 和 P38 激酶级联是一个稳健的系统。
