The effect of some antiinflammatory drugs on collagen of rat fibrous cartilage.

The use of SDS-polyacrylamide gel electrophoresis of the cyanogen bromide derived peptides from fibrous cartilage collagens enabled to calculate type I to type II collagen ratio in this tissue. Some of the investigated drugs (acetylsalicylic acid, colchicine) changed this ratio without having a significant effect on total collagen content in fibrous cartilage.