某些抗炎药物对大鼠纤维软骨胶原蛋白的影响。
The effect of some antiinflammatory drugs on collagen of rat fibrous cartilage.
作者信息
Wróbel K, Pałka J, Galewska Z
机构信息
Department of Biochemistry, Medical Academy of Białystok, Poland.
出版信息
Acta Biochim Pol. 1990;37(2):317-21.
PMID:2072987
Abstract
The use of SDS-polyacrylamide gel electrophoresis of the cyanogen bromide derived peptides from fibrous cartilage collagens enabled to calculate type I to type II collagen ratio in this tissue. Some of the investigated drugs (acetylsalicylic acid, colchicine) changed this ratio without having a significant effect on total collagen content in fibrous cartilage.
摘要
使用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳法对来自纤维软骨胶原蛋白的溴化氰衍生肽进行分析，从而能够计算该组织中I型胶原与II型胶原的比例。一些研究的药物（乙酰水杨酸、秋水仙碱）改变了这一比例，但对纤维软骨中的总胶原蛋白含量没有显著影响。
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